Human HEPACAM2 protein (Recombinant) (N-His) (STJP011014)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HEPACAM2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HEPACAM2 |
| Gene ID | 253012 |
| Uniprot ID | HECA2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu32-Pro351 |
Additional Info
| Post Translational Modifications | Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. N-glycosylated. |
| Function | Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. |
| Protein Name | Hepacam Family Member 2Mitotic Kinetics Regulator |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinCytoplasmCytoskeletonSpindleMicrotubule Organizing CenterCentrosomeMidbodyIn InterphaseLocalizes To The Golgi ApparatusLocalizes To Centrosomes And Spindles During ProphasePrometaphaseAnd Metaphase Of MitosisAnd To Midbodies At TelophaseTranslocation To Mitotic Centrosomes Is The Result Of Poly-Adp-Ribosylation (Parsylation) |
| Alternative Protein Names | Hepacam Family Member 2 proteinMitotic Kinetics Regulator proteinHEPACAM2 proteinMIKI proteinUNQ305 proteinPRO346 protein |
Information sourced from Uniprot.org