SDS-PAGE gel of recombinant human HEPACAM2 protein under reducing conditions

Human HEPACAM2 protein (Recombinant) (His-Tag) (STJP018391)

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STJP018391
€161.40 - €886.20
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Short Description :Recombinant-Human HEPACAM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:HEPACAM2
Gene ID:253012
Uniprot ID:HECA2_HUMAN
Accession Number:NP_001034461
Immunogen:Human
Immunogen Region:32-351aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSLKVTVPS HTVHGVRGQA LYLPVHYGFH TPASDIQIIW LFERPHTMPK YLLGSVNKSV VPDLEYQHKF TMMPPNASLL INPLQFPDEG NYIVKVNIQG NGTLSASQKI QVTVDDPVTK PVVQIHPPSG AVEYVGNMTL TCHVEGGTRL AYQWLKNGRP VHTSSTYSFS PQNNTLHIAP VTKEDIGNYS CLVRNPVSEM ESDIIMPI
Tissue Specificity Widely expressed.
Post Translational Modifications Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. N-glycosylated.
Function Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.
Protein Name Hepacam Family Member 2
Mitotic Kinetics Regulator
Database Links
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Cytoskeleton
Spindle
Microtubule Organizing Center
Centrosome
Midbody
In Interphase
Localizes To The Golgi Apparatus
Localizes To Centrosomes And Spindles During Prophase
Prometaphase
And Metaphase Of Mitosis
And To Midbodies At Telophase
Translocation To Mitotic Centrosomes Is The Result Of Poly-Adp-Ribosylation (Parsylation)
Alternative Protein Names Hepacam Family Member 2 protein
Mitotic Kinetics Regulator protein
HEPACAM2 protein
MIKI protein
UNQ305 protein
PRO346 protein

Information sourced from Uniprot.org

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