Human Hematopoietic Prostaglandin D Synthase/HPGDS protein (Recombinant) (His-Tag) (STJP017667)

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STJP017667
€161.40 - €886.20
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Hematopoietic Prostaglandin D Synthase/HPGDS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.15M NaCl, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HPGDS
Gene ID: 27306
Uniprot ID: HPGDS_HUMAN
Immunogen Region: 1-199aa
Accession Number: NP_055300
Immunogen: Human
Immunogen Sequence: MPNYKL TYFNMRGRAE IIRYIFAYLD IQYEDHRIEQ ADWPEIKSTL PFGKIPILEV DGLTLHQSLA IARYLTKNTD LAGNTEMEQC HVDAIVDTLD DFMSCFPWAE KKQDVKEQMF NELLTYNAPH LMQDLDTYLG GREWLIGNSV TWADFYWEIC STTLLVFKPD LLDNHPRLVT LRKKVQAIPA VANWIKRRPQ TKL
Tissue Specificity Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.
Function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Protein Name Hematopoietic Prostaglandin D Synthase
H-Pgds
Gst Class-Sigma
Glutathione S-Transferase
Glutathione-Dependent Pgd Synthase
Glutathione-Requiring Prostaglandin D Synthase
Prostaglandin-H2 D-Isomerase
Database Links Reactome: R-HSA-156590
Reactome: R-HSA-2162123
Cellular Localisation Cytoplasm
Alternative Protein Names Hematopoietic Prostaglandin D Synthase protein
H-Pgds protein
Gst Class-Sigma protein
Glutathione S-Transferase protein
Glutathione-Dependent Pgd Synthase protein
Glutathione-Requiring Prostaglandin D Synthase protein
Prostaglandin-H2 D-Isomerase protein
HPGDS protein
GSTS protein
PGDS protein
PTGDS2 protein

Information sourced from Uniprot.org

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