• Human HCVADR/CXADR protein (Recombinant) (C-His) (STJP001071)

Human HCVADR/CXADR protein (Recombinant) (C-His) (STJP001071)

SKU:
STJP001071

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human HCVADR/CXADR-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: CXADR
Gene ID: 1525
Uniprot ID: CXAR_HUMAN
Immunogen: Recombinant Human HCVADR/CXADR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu20-Gly237) of human CXADR/CAR (Accession #NP_001329.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Post Translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane.
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Protein Name Coxsackievirus And Adenovirus Receptor
Car
Hcar
Cvb3-Binding Protein
Coxsackievirus B-Adenovirus Receptor
Hcvadr
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Basolateral Cell Membrane
Cell Junction
Tight Junction
Adherens Junction
In Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens Junctions
In Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical Surface
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Secreted
Alternative Protein Names Coxsackievirus And Adenovirus Receptor protein
Car protein
Hcar protein
Cvb3-Binding Protein protein
Coxsackievirus B-Adenovirus Receptor protein
Hcvadr protein
CXADR protein
CAR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance