| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | Please contact us for more information. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C at 1 Mu g/mL (100 Mu L/well) can bind GUCY2C Rabbit pAb with a linear range of 1-144 ng/mL. |
| Gene Symbol: | GUCY2C |
| Gene ID: | 2984 |
| Uniprot ID: | GUC2C_HUMAN |
| Immunogen: | Recombinant Human Guanylyl cyclase C/GUCY2C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Gln430) of human GUCY2C/Guanylyl cyclase (Accession #NP_004954.2) fused with a 6×His, Avi tag at t |
| Immunogen Sequence: | SQVSQNCHNGSYEISVLMMG NSAFAEPLKNLEDAVNEGLE IVRGRLQNAGLNVTVNATFM YSDGLIHNSGDCRSSTCEGL DLLRKISNAQRMGCVLIGPS CTYSTFQMYLDTELSYPMIS AGSFGLSCDYKETLTRLMSP ARKLMYFLVNFWKTNDLPFK TYSWSTSYVYKNGTETEDCF WYLNALEASVSYFSHELGFK VVLRQDKEFQDILMDHNRKS NVIIMCGGPEFLYKLKGDR |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Protein Names | Guanylyl Cyclase C proteinGc-C proteinHeat-Stable Enterotoxin Receptor proteinSta Receptor proteinHstar proteinIntestinal Guanylate Cyclase proteinGUCY2C proteinGUC2C proteinSTAR protein |
Information sourced from Uniprot.org