Human GRK6 protein (Recombinant) (N-His) (STJP004739)

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STJP004739
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GRK6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GRK6
Gene ID: 2870
Uniprot ID: GRK6_HUMAN
Immunogen Region: Phe186-Phe448
Immunogen: Homo sapiens (Human)
Post Translational Modifications It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Protein Name G Protein-Coupled Receptor Kinase 6
G Protein-Coupled Receptor Kinase Grk6
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Lipid-Anchor
Alternative Protein Names G Protein-Coupled Receptor Kinase 6 protein
G Protein-Coupled Receptor Kinase Grk6 protein
GRK6 protein
GPRK6 protein

Information sourced from Uniprot.org

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