Human GP6 protein (Recombinant) (N-His) (STJP006025)

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STJP006025
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Short Description :Recombinant-Human GP6-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:GP6
Gene ID:51206
Uniprot ID:GPVI_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Tyr86-Thr231
Post Translational Modifications N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Protein Name Platelet Glycoprotein Vi
Gpvi
Glycoprotein 6
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202733
Reactome: R-HSA-75892
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Protein Names Platelet Glycoprotein Vi protein
Gpvi protein
Glycoprotein 6 protein
GP6 protein

Information sourced from Uniprot.org

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