SDS-PAGE gel of recombinant human GORASP2 protein stained with Coomassie blue

Human GORASP2 protein (Recombinant) (His-Tag) (STJP019060)

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STJP019060
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Short Description :Recombinant-Human GORASP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4)
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:GORASP2
Gene ID:26003
Uniprot ID:GORS2_HUMAN
Accession Number:NP_056345.3
Immunogen:Human
Immunogen Region:1-452aa
Immunogen Sequence:MGSSQSV EIPGGGTEGY HVLRVQENSP GHRAGLEPFF DFIVSINGSR LNKDNDTLKD LLKANVEKPV KMLIYSSKTL ELRETSVTPS NLWGGQGLLG VSIRFCSFDG ANENVWHVLE VESNSPAALA GLRPHSDYII GADTVMNESE DLFSLIETHE AKPLKLYVYN TDTDNCREVI ITPNSAWGGE GSLGCGIGYG YLHRIP
Post Translational Modifications Myristoylated. Myristoylation is essential for the Golgi targeting. Palmitoylated. Phosphorylated in mitotic cells. ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane.
Function Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane.
Protein Name Golgi Reassembly-Stacking Protein 2
Grs2
Golgi Phosphoprotein 6
Golph6
Golgi Reassembly-Stacking Protein Of 55 Kda
Grasp55
P59
Database Links Reactome: R-HSA-162658
Cellular Localisation Golgi Apparatus Membrane
Lipid-Anchor
Endoplasmic Reticulum Membrane
Golgi Apparatus
Detected In The Intermediate Golgi
Membrane-Associated
Er Stress Triggers Its Relocalization From Golgi To Er Membrane
Alternative Protein Names Golgi Reassembly-Stacking Protein 2 protein
Grs2 protein
Golgi Phosphoprotein 6 protein
Golph6 protein
Golgi Reassembly-Stacking Protein Of 55 Kda protein
Grasp55 protein
P59 protein
GORASP2 protein
GOLPH6 protein

Information sourced from Uniprot.org

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