| Function | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase. |
| Protein Name | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1Transducin Alpha-1 Chain |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-418594 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentLocalizes Mainly In The Outer Segment In The Dark-Adapted StateWhereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted StateDuring Dark-Adapted ConditionsIn The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light |
| Alternative Protein Names | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1 proteinTransducin Alpha-1 Chain proteinGNAT1 proteinGNATR protein |
Information sourced from Uniprot.org
