Human GNAT1 protein (Recombinant) (N-His) (STJP007783)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GNAT1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GNAT1 |
| Gene ID | 2779 |
| Uniprot ID | GNAT1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Phe350 |
Additional Info
| Function | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase. |
| Protein Name | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1Transducin Alpha-1 Chain |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-418594 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentLocalizes Mainly In The Outer Segment In The Dark-Adapted StateWhereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted StateDuring Dark-Adapted ConditionsIn The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light |
| Alternative Protein Names | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1 proteinTransducin Alpha-1 Chain proteinGNAT1 proteinGNATR protein |
Information sourced from Uniprot.org