Human GHRL protein (Recombinant) (N-His) (STJP006138)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GHRL-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GHRL |
| Gene ID | 51738 |
| Uniprot ID | GHRL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser25-Lys117 |
Additional Info
| Post Translational Modifications | O-octanoylated by GOAT/MBOAT4. O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Also O-acetylated and O-butyrylated on Ser-26 to minor levels. Amidation of Leu-98 is essential for obestatin activity. |
| Function | Ghrelin-27: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Ghrelin-28: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Protein Name | Appetite-Regulating HormoneGrowth Hormone SecretagogueGrowth Hormone-Releasing PeptideMotilin-Related PeptideProtein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28Ghrelin - Obestatin |
| Database Links | Reactome: R-HSA-375276 Q9UBU3-1Reactome: R-HSA-416476 Q9UBU3-1Reactome: R-HSA-422085 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Appetite-Regulating Hormone proteinGrowth Hormone Secretagogue proteinGrowth Hormone-Releasing Peptide proteinMotilin-Related Peptide proteinProtein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28 proteinGhrelin - Obestatin proteinGHRL proteinMTLRP proteinUNQ524 proteinPRO1066 protein |
Information sourced from Uniprot.org