Human GDNFR-alpha-1/GFRA1 protein (Recombinant) (C-6His) (STJP020089)

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STJP020089
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g of the protein by LAL method
Gene Symbol: GFRA1
Gene ID: 2674
Uniprot ID: GFRA1_HUMAN
Immunogen Region: Asp25-Ile426
Immunogen: Recombinant Human GDNFR-alpha-1/GFRA1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp25-Ile426) of Human GDNFR-alpha-1/GFRA1 (Accession #NP_665736) fused with His at the C-terminus.
Immunogen Sequence: DRLDCVKASDQCLKEQSCST KYRTLRQCVAGKETNFSLAS GLEAKDECRSAMEALKQKSL YNCRCKRGMKKEKNCLRIYW SMYQSLQGNDLLEDSPYEPV NSRLSDIFRVVPFISDVFQQ VEHIPKGNNCLDAAKACNLD DICKKYRSAYITPCTTSVSN DVCNRRKCHKALRQFFDKVP AKHSYGMLFCSCRDIACTER RRQTIVPVCSYEEREKPNCL NLQDSCKTNYICRSRLADF
Function Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-1
Gdnf Receptor Alpha-1
Gdnfr-Alpha-1
Gfr-Alpha-1
Ret Ligand 1
Tgf-Beta-Related Neurotrophic Factor Receptor 1
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Reactome: R-HSA-9830674
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Trans-Golgi Network
Endosome
Multivesicular Body
Localizes Mainly To The Plasma Membrane
In The Presence Of Sorl1
Shifts To Vesicular Structures
Including Trans-Golgi Network
Endosomes And Multivesicular Bodies
Alternative Protein Names Gdnf Family Receptor Alpha-1 protein
Gdnf Receptor Alpha-1 protein
Gdnfr-Alpha-1 protein
Gfr-Alpha-1 protein
Ret Ligand 1 protein
Tgf-Beta-Related Neurotrophic Factor Receptor 1 protein
GFRA1 protein
GDNFRA protein
RETL1 protein
TRNR1 protein

Information sourced from Uniprot.org

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