| Short Description : | Recombinant-Human GDNFR-alpha-1/GFRA1-C-6His protein was developed in hek293 cells using the region Asp25-Ile426. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method |
| Gene Symbol: | GFRA1 |
| Gene ID: | 2674 |
| Uniprot ID: | GFRA1_HUMAN |
| Immunogen: | Recombinant Human GDNFR-alpha-1/GFRA1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp25-Ile426) of Human GDNFR-alpha-1/GFRA1 (Accession #NP_665736) fused with His at the C-terminus. |
| Immunogen Region: | Asp25-Ile426 |
| Immunogen Sequence: | DRLDCVKASDQCLKEQSCST KYRTLRQCVAGKETNFSLAS GLEAKDECRSAMEALKQKSL YNCRCKRGMKKEKNCLRIYW SMYQSLQGNDLLEDSPYEPV NSRLSDIFRVVPFISDVFQQ VEHIPKGNNCLDAAKACNLD DICKKYRSAYITPCTTSVSN DVCNRRKCHKALRQFFDKVP AKHSYGMLFCSCRDIACTER RRQTIVPVCSYEEREKPNCL NLQDSCKTNYICRSRLADF |
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Protein Names | Gdnf Family Receptor Alpha-1 proteinGdnf Receptor Alpha-1 proteinGdnfr-Alpha-1 proteinGfr-Alpha-1 proteinRet Ligand 1 proteinTgf-Beta-Related Neurotrophic Factor Receptor 1 proteinGFRA1 proteinGDNFRA proteinRETL1 proteinTRNR1 protein |
Information sourced from Uniprot.org
