| Host: |
E. coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its ability to agglutinate mouse red blood cells. The ED50 for this effect is 0.5-3 Mu g/mL. |
| Gene Symbol: |
LGALS1 |
| Gene ID: |
3956 |
| Uniprot ID: |
LEG1_HUMAN |
| Immunogen: |
Recombinant Human Galectin-1/LGALS1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala2-Asp135) of human Galectin-1 (Accession #NP_002296.1). |
| Immunogen Sequence: |
ACGLVASNLNLKPGECLRVR GEVAPDAKSFVLNLGKDSNN LCLHFNPRFNAHGDANTIVC NSKDGGAWGTEQREAVFPFQ PGSVAEVCITFDQANLTVKL PDGYEFKFPNRLNLEAINYM AADGDFKIKCVAFD |
| Tissue Specificity | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. |
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. |
| Protein Name | Galectin-1Gal-114 Kda Laminin-Binding ProteinHlbp1414 Kda LectinBeta-Galactoside-Binding Lectin L-14-IGalaptinHblHplLactose-Binding Lectin 1Lectin Galactoside-Binding Soluble 1Putative Mapk-Activating Protein Pm12S-Lac Lectin 1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCytoplasmCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Galectin-1 proteinGal-1 protein14 Kda Laminin-Binding Protein proteinHlbp14 protein14 Kda Lectin proteinBeta-Galactoside-Binding Lectin L-14-I proteinGalaptin proteinHbl proteinHpl proteinLactose-Binding Lectin 1 proteinLectin Galactoside-Binding Soluble 1 proteinPutative Mapk-Activating Protein Pm12 proteinS-Lac Lectin 1 proteinLGALS1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
