| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
FSTL3 |
| Gene ID: |
10272 |
| Uniprot ID: |
FSTL3_HUMAN |
| Immunogen: |
Recombinant Human Follistatin-like protein 3/FSTL3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met27-Val263) of human FLRG (Accession #NP_005851.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MGSGNPAPGGVCWLQQGQEA TCSLVLQTDVTRAECCASGN IDTAWSNLTHPGNKINLLGF LGLVHCLPCKDSCDGVECGP GKACRMLGGRPRCECAPDCS GLPARLQVCGSDGATYRDEC ELRAARCRGHPDLSVMYRGR CRKSCEHVVCPRPQSCVVDQ TGSAHCVVCRAAPCPVPSSP GQELCGNNNVTYISSCHMRQ ATCFLGRSIGVRHAGSCAGT PEEPPGGESAEEEENFV |
| Tissue Specificity | Expressed in a wide range of tissues. |
| Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiation. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| Protein Name | Follistatin-Related Protein 3Follistatin-Like Protein 3Follistatin-Related Gene Protein |
| Database Links | Reactome: R-HSA-2473224Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: NucleusAlthough Alternative Initiation Has Been Demonstrated And Resulted In Different LocalizationThe Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To |
| Alternative Protein Names | Follistatin-Related Protein 3 proteinFollistatin-Like Protein 3 proteinFollistatin-Related Gene Protein proteinFSTL3 proteinFLRG proteinUNQ674 proteinPRO1308 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
