Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human Follistatin-like protein 3/FSTL3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Gene Symbol: |
FSTL3 |
Gene ID: |
10272 |
Uniprot ID: |
FSTL3_HUMAN |
Immunogen: |
Recombinant Human Follistatin-like protein 3/FSTL3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met27-Val263) of human FLRG (Accession #NP_005851.1) fused with a 6×His tag at the C-terminus. |
Tissue Specificity | Expressed in a wide range of tissues. |
Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiationc. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
Protein Name | Follistatin-Related Protein 3Follistatin-Like Protein 3Follistatin-Related Gene Protein |
Database Links | Reactome: R-HSA-2473224Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
Cellular Localisation | Isoform 1: SecretedIsoform 2: NucleusAlthough Alternative Initiation Has Been Demonstrated And Resulted In Different LocalizationThe Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To |
Alternative Protein Names | Follistatin-Related Protein 3 proteinFollistatin-Like Protein 3 proteinFollistatin-Related Gene Protein proteinFSTL3 proteinFLRG proteinUNQ674 proteinPRO1308 protein |
Information sourced from Uniprot.org
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