Human Follistatin-like protein 3/FSTL3 protein (Recombinant) (C-His) (STJP001086)

SKU:

STJP001086

$103.28 - $335.48

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Follistatin-like protein 3/FSTL3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	FSTL3
Gene ID:	10272
Uniprot ID:	FSTL3_HUMAN
Immunogen:	Recombinant Human Follistatin-like protein 3/FSTL3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met27-Val263) of human FLRG (Accession #NP_005851.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Expressed in a wide range of tissues.
Function	Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiationc. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Protein Name	Follistatin-Related Protein 3 Follistatin-Like Protein 3 Follistatin-Related Gene Protein
Database Links	Reactome: R-HSA-2473224 Reactome: R-HSA-381426 Reactome: R-HSA-8957275
Cellular Localisation	Isoform 1: Secreted Isoform 2: Nucleus Although Alternative Initiation Has Been Demonstrated And Resulted In Different Localization The Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To
Alternative Protein Names	Follistatin-Related Protein 3 protein Follistatin-Like Protein 3 protein Follistatin-Related Gene Protein protein FSTL3 protein FLRG protein UNQ674 protein PRO1308 protein

Information sourced from Uniprot.org

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