Human FMO3 protein (Recombinant) (N-His) (STJP004547)

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STJP004547
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FMO3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FMO3
Gene ID: 2328
Uniprot ID: FMO3_HUMAN
Immunogen Region: Lys280-Thr532
Immunogen: Homo sapiens (Human)
Function Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Protein Name Flavin-Containing Monooxygenase 3
Dimethylaniline Monooxygenase N-Oxide-Forming 3
Dimethylaniline Oxidase 3
Fmo Ii
Fmo Form 2
Hepatic Flavin-Containing Monooxygenase 3
Fmo 3
Trimethylamine Monooxygenase
Database Links Reactome: R-HSA-217271
Reactome: R-HSA-5579019
Cellular Localisation Microsome Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Alternative Protein Names Flavin-Containing Monooxygenase 3 protein
Dimethylaniline Monooxygenase N-Oxide-Forming 3 protein
Dimethylaniline Oxidase 3 protein
Fmo Ii protein
Fmo Form 2 protein
Hepatic Flavin-Containing Monooxygenase 3 protein
Fmo 3 protein
Trimethylamine Monooxygenase protein
FMO3 protein

Information sourced from Uniprot.org