SDS-PAGE gel of recombinant human FKBP36 FKBP6 protein 3µg under reducing conditions Coomassie blue stain

Human FKBP36/FKBP6 protein (Recombinant) (His-Tag) (STJP016700)

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STJP016700
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Short Description :Recombinant-Human FKBP36/FKBP6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% Glycerol, 1mM EDTA, 0.2M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Specific activity is > 190nmol/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAPF-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
Gene Symbol:FKBP6
Gene ID:8468
Uniprot ID:FKBP6_HUMAN
Accession Number:NP_003593.3
Immunogen:Human
Immunogen Region:1-327aa
Immunogen Sequence: MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK FCALSAEQQD QFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL LRRRSA
Tissue Specificity Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
Function Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
Protein Name Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6
Inactive Ppiase Fkbp6
36 Kda Fk506-Binding Protein
36 Kda Fkbp
Fkbp-36
Fk506-Binding Protein 6
Fkbp-6
Immunophilin Fkbp36
Database Links Reactome: R-HSA-1221632
Reactome: R-HSA-5601884
Cellular Localisation Cytoplasm
Nucleus
In Spermatocytes
It Colocalizes With Piwil1 In Large Cytoplasmic Granules
Does Not Localize To The Synaptonemal Complex
Alternative Protein Names Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 protein
Inactive Ppiase Fkbp6 protein
36 Kda Fk506-Binding Protein protein
36 Kda Fkbp protein
Fkbp-36 protein
Fk506-Binding Protein 6 protein
Fkbp-6 protein
Immunophilin Fkbp36 protein
FKBP6 protein
FKBP36 protein

Information sourced from Uniprot.org

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