Human FIL1d (Interleukin 1 Delta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015309)
SPECIFICATIONS
General Information
| Short Description | This FIL1d Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 5.7pg/mL |
| Detection Limit | 15.6-1000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | IL36RN |
| Gene ID | 26525 |
| Uniprot ID | I36RA_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
| Post Translational Modifications | |
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative ELISA Names | Interleukin-36 Receptor Antagonist Protein ELISA kitIl-36ra ELISA kitFil1 Delta ELISA kitIl-1-Related Protein 3 ELISA kitIl-1rp3 ELISA kitInterleukin-1 Hy1 ELISA kitIl-1hy1 ELISA kitInterleukin-1 Delta ELISA kitIl-1 Delta ELISA kitInterleukin-1 Family Member 5 ELISA kitIl-1f5 ELISA kitInterleukin-1 Receptor Antagonist Homolog 1 ELISA kitIl-1ra Homolog 1 ELISA kitInterleukin-1-Like Protein 1 ELISA kitIl-1l1 ELISA kitIL36RN ELISA kitFIL1D ELISA kitIL1F5 ELISA kitIL1HY1 ELISA kitIL1L1 ELISA kitIL1RP3 ELISA kitUNQ1896 ELISA kitPRO4342 ELISA kit |
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Information sourced from Uniprot.org