• Human FGF-12 protein (Recombinant) (C-His) (STJP000840)
  • Human FGF-12 protein (Recombinant) (C-His) (STJP000840)
  • Human FGF-12 protein (Recombinant) (C-His) (STJP000840)
  • Human FGF-12 protein (Recombinant) (C-His) (STJP000840)

Human FGF-12 protein (Recombinant) (C-His) (STJP000840)

SKU:
STJP000840

Current Stock:
Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, 1mM DTT, 300mM NaCl, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1.0 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGFR4 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human FGF12 with a linear range of 35-100 ng/mL.
Gene Symbol: FGF12
Gene ID: 2257
Uniprot ID: FGF12_HUMAN
Immunogen Region: Met1-Thr181
Immunogen: Recombinant Human FGF-12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Thr181) of human FGF-12 (Accession #NP_004104.3) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: MESKEPQLKGIVTRLFSQQG YFLQMHPDGTIDGTKDENSD YTLFNLIPVGLRVVAIQGVK ASLYVAMNGEGYLYSSDVFT PECKFKESVFENYYVIYSST LYRQQESGRAWFLGLNKEGQ IMKGNRVKKTKPSSHFVPKP IEVCMYREPSLHEIGEKQGR SRKSSGTPTMNGGKVVNQDS T
Tissue Specificity Brain, eye and testis.highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall.in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
Function Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Protein Name Fibroblast Growth Factor 12
Fgf-12
Fibroblast Growth Factor Homologous Factor 1
Fhf-1
Myocyte-Activating Factor
Database Links Reactome: R-HSA-5576892
Cellular Localisation Nucleus
Alternative Protein Names Fibroblast Growth Factor 12 protein
Fgf-12 protein
Fibroblast Growth Factor Homologous Factor 1 protein
Fhf-1 protein
Myocyte-Activating Factor protein
FGF12 protein
FGF12B protein
FHF1 protein

Information sourced from Uniprot.org

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