Human FCER1A protein (Recombinant-Active) (C-His) (STJP011860)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human FCER1A-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Immobilised FITC anti-human Fc Epsilon RI Alpha Antibody at 1 Mu g/mL (25 Mu L/well) can bind human FCER1A with a linear range of 0.46-3.15 ng/mL. |
Target Information
| Gene Symbol | FCER1A |
| Gene ID | 2205 |
| Uniprot ID | FCERA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val26-Gln205 |
Additional Info
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit AlphaFc-Epsilon Ri-AlphaFceriIge Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha proteinFc-Epsilon Ri-Alpha proteinFceri proteinIge Fc Receptor Subunit Alpha proteinFCER1A proteinFCE1A protein |
Information sourced from Uniprot.org