• Human Fc epsilon RII/CD23 protein (Recombinant) (N-his) (STJP001400)

Human Fc epsilon RII/CD23 protein (Recombinant) (N-his) (STJP001400)

SKU:
STJP001400

£89.50 - £274.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Gene Symbol: FCER2
Gene ID: 2208
Uniprot ID: FCER2_HUMAN
Immunogen: Recombinant Human Fc epsilon RII/CD23 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp 48-Ser321) of human CD23/Fc epsilon RII (Accession #NP_001993.2.) fused with a 6×His tag at the N-terminus
Immunogen Sequence: DTTQSLKQLEERAARNVSQV SKNLESHHGDQMAQKSQSTQ ISQELEELRAEQQRLKSQDL ELSWNLNGLQADLSSFKSQE LNERNEASDLLERLREEVTK LRMELQVSSGFVCNTCPEKW INFQRKCYYFGKGTKQWVHA RYACDDMEGQLVSIHSPEEQ DFLTKHASHTGSWIGLRNLD LKGEFIWVDGSHVDYSNWAP GEPTSRSQGEDCVMMRGSGR WNDAFCDRKLGAWVCDRLA
Post Translational Modifications N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
Function Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway.
Protein Name Low Affinity Immunoglobulin Epsilon Fc Receptor
Blast-2
C-Type Lectin Domain Family 4 Member J
Fc-Epsilon-Rii
Immunoglobulin E-Binding Factor
Lymphocyte Ige Receptor
Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form
Database Links Reactome: R-HSA-2197563
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Lipid-Anchor
Secreted
Also Exists As A Soluble Excreted Form
Scd23
Alternative Protein Names Low Affinity Immunoglobulin Epsilon Fc Receptor protein
Blast-2 protein
C-Type Lectin Domain Family 4 Member J protein
Fc-Epsilon-Rii protein
Immunoglobulin E-Binding Factor protein
Lymphocyte Ige Receptor protein
Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form protein
FCER2 protein
CD23A protein
CLEC4J protein
FCE2 protein
IGEBF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance