Human ETHE1 protein (Recombinant) (N-His) (STJP010790)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ETHE1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ETHE1 |
| Gene ID | 23474 |
| Uniprot ID | ETHE1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile23-Ala254 |
Additional Info
| Function | Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. |
| Protein Name | Persulfide Dioxygenase Ethe1 - MitochondrialEthylmalonic Encephalopathy Protein 1Hepatoma Subtracted Clone One ProteinSulfur Dioxygenase Ethe1 |
| Database Links | Reactome: R-HSA-1614517 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Matrix |
| Alternative Protein Names | Persulfide Dioxygenase Ethe1 - Mitochondrial proteinEthylmalonic Encephalopathy Protein 1 proteinHepatoma Subtracted Clone One Protein proteinSulfur Dioxygenase Ethe1 proteinETHE1 proteinHSCO protein |
Information sourced from Uniprot.org