| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | EREG |
| Gene ID: | 2069 |
| Uniprot ID: | EREG_HUMAN |
| Immunogen Region: | Val63-Leu108 |
| Immunogen: | Recombinant Human EREG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val63-Leu108) of Human EREG (Accession #NP_001423.1) fused with a hFc tag at the N-terminus. |
| Immunogen Sequence: | QGVFEDCCLAYHYPIGWAVL RRAWTYRIQEVSGSCNLPAA IFYLPKRHRKVCGNPKSREV QRAMKLLDARNKVFAKLHHN TQTFQAGPHAVKKLSSGNSK LSSSKFSNPISSSKRNVSLL ISANSGL |
| Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
| Function | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. |
| Protein Name | Proepiregulin Cleaved Into - EpiregulinEpr |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-177929Reactome: R-HSA-179812Reactome: R-HSA-180292Reactome: R-HSA-180336Reactome: R-HSA-182971Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-212718Reactome: R-HSA-2219530Reactome: R-HSA-5638303Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8863795Reactome: R-HSA-9009391Reactome: R-HSA-9634638Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Epiregulin: SecretedExtracellular SpaceProepiregulin: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Proepiregulin Cleaved Into - Epiregulin proteinEpr proteinEREG protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
