| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human EPCR-Fc-Tag protein was developed from hek293 and has a target region of Fc-Tag. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Gene Symbol: |
PROCR |
| Gene ID: |
10544 |
| Uniprot ID: |
EPCR_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
DNA sequence encoding the extracellular domain of Human PROCR including a C-terminal human IgG1-Fc tag was expressed in HEK293 Cells. NA |
| Immunogen Sequence: |
SQDASDGLQR LHMLQISYFR DPYHVWYQGN ASLGGHLTHV LEGPDTNTTI IQLQPLQEPE SWARTQSGLQ SYLLQFHGLV RLVHQERTLA FPLTIRCFLG CELPPEGSRA HVFFEVAVNG SSFVSFRPER ALWQADTQVT SGVVTFTLQQ LNAYNRTRYE LREFLEDTCV QYVQKHISAE NTKGSQTSRS NA |
| Tissue Specificity | Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. |
| Post Translational Modifications | N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. |
| Function | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation. |
| Protein Name | Endothelial Protein C ReceptorActivated Protein C ReceptorApc ReceptorEndothelial Cell Protein C ReceptorCd Antigen Cd201 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Endothelial Protein C Receptor proteinActivated Protein C Receptor proteinApc Receptor proteinEndothelial Cell Protein C Receptor proteinCd Antigen Cd201 proteinPROCR proteinEPCR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
