| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 14e-Bp1Eif4e-Binding Protein 1Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1Phas-I |
| Database Links | Reactome: R-HSA-166208Reactome: R-HSA-72662 |
| Cellular Localisation | CytoplasmNucleusLocalization To The Nucleus Is Unaffected By Phosphorylation Status |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 protein4e-Bp1 proteinEif4e-Binding Protein 1 proteinPhosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 proteinPhas-I proteinEIF4EBP1 protein |
Information sourced from Uniprot.org
