Human EIF3G protein (Recombinant) (N-GST & C-His) (STJP010750)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EIF3G-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | EIF3G |
| Gene ID | 8666 |
| Uniprot ID | EIF3G_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln230-Asn320 |
Additional Info
| Function | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit GEif3gEukaryotic Translation Initiation Factor 3 Rna-Binding SubunitEif-3 Rna-Binding SubunitEukaryotic Translation Initiation Factor 3 Subunit 4Eif-3-DeltaEif3 P42Eif3 P44 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | CytoplasmNucleusPerinuclear RegionColocalizes With Aifm1 In The Nucleus And Perinuclear Region |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 3 Subunit G proteinEif3g proteinEukaryotic Translation Initiation Factor 3 Rna-Binding Subunit proteinEif-3 Rna-Binding Subunit proteinEukaryotic Translation Initiation Factor 3 Subunit 4 proteinEif-3-Delta proteinEif3 P42 proteinEif3 P44 proteinEIF3G proteinEIF3S4 protein |
Information sourced from Uniprot.org