| Post Translational Modifications | Phosphorylation at Ser-226 by PLK1 before mitosis prevents interaction with PCM1 and localization to centriolar satellites. Thereby, it negatively regulates the localization of the BBSome to centriolar satellites. |
| Function | Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum. Also indirectly involved in heart development through its function in ciliogenesis. |
| Protein Name | Cilium Assembly Protein Dzip1Daz-Interacting Protein 1/2Daz-Interacting Zinc Finger Protein 1 |
| Database Links | Reactome: R-HSA-5632684 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentriolar SatelliteCentrioleNucleusNucleus SpeckleLocalizes To The Centriole In Cells Lacking Cilia And To The Cilium Basal Body In Ciliated CellsAt The Exit Of MitosisWhen The Primary Cilium Is Reassembled In Daughter CellsLocalizes At The Mother Centriole That Acts As The Basal Body Of The Assembling Primary Cilium And Also Accumulates At The Ciliary Base That Constitutes A Diffusion Barrier For Ciliary Proteins |
| Alternative Protein Names | Cilium Assembly Protein Dzip1 proteinDaz-Interacting Protein 1/2 proteinDaz-Interacting Zinc Finger Protein 1 proteinDZIP1 proteinDZIP proteinDZIP2 proteinKIAA0996 protein |
Information sourced from Uniprot.org
