Human DUSP1 protein (Recombinant) (C-His) (STJP014465)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DUSP1-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | DUSP1 |
| Gene ID | 1843 |
| Uniprot ID | DUS1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly173-Ala314 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. |
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Protein Name | Dual Specificity Protein Phosphatase 1Dual Specificity Protein Phosphatase Hvh1Mitogen-Activated Protein Kinase Phosphatase 1Map Kinase Phosphatase 1Mkp-1Protein-Tyrosine Phosphatase Cl100 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Dual Specificity Protein Phosphatase 1 proteinDual Specificity Protein Phosphatase Hvh1 proteinMitogen-Activated Protein Kinase Phosphatase 1 proteinMap Kinase Phosphatase 1 proteinMkp-1 proteinProtein-Tyrosine Phosphatase Cl100 proteinDUSP1 proteinCL100 proteinMKP1 proteinPTPN10 proteinVH1 protein |
Information sourced from Uniprot.org