Human DTD1 protein (Recombinant) (His-Tag) (STJP017938)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DTD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DTD1 |
| Gene ID | 92675 |
| Uniprot ID | DTD1_HUMAN |
| Accession Number | NP_543010 |
| Immunogen | Human |
| Immunogen Region | 1-209aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMKAVVQR VTRASVTVGG EQISAIGRGI CVLLGISLED TQKELEHMVR KILNLRVFED ESGKHWSKSV MDKQYEILCV SQFTLQCVLK GNKPDFHLAM PTEQAEGFYN SFLEQLRKTY RPELIKDGKF GAYMQVHIQN DGPVTIELES PAPGTATSDP KQLSKLEKQQ QRKEKTRAKG PSESSKERNT PRKEDRSASS GAEGDVSS |
Additional Info
| Tissue Specificity | Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. |
| Post Translational Modifications | Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45. |
| Function | Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis.rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. |
| Protein Name | D-Aminoacyl-Trna Deacylase 1DtdDna-Unwinding Element-Binding Protein BDue-BGly-Trna(Ala DeacylaseHistidyl-Trna Synthase-Related |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmAssociated With Chromatin At Some Replication Origins Containing Functional Dna-Unwinding Elements |
| Alternative Protein Names | D-Aminoacyl-Trna Deacylase 1 proteinDtd proteinDna-Unwinding Element-Binding Protein B proteinDue-B proteinGly-Trna(Ala Deacylase proteinHistidyl-Trna Synthase-Related proteinDTD1 proteinC20orf88 proteinDUEB proteinHARS2 protein |
Information sourced from Uniprot.org