Human DTD1 protein (Recombinant) (C-His) (STJP013727)

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STJP013727-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DTD1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: DTD1
Gene ID: 92675
Uniprot ID: DTD1_HUMAN
Immunogen Region: Met1-Pro209
Immunogen: Homo sapiens (Human)
Post Translational Modifications Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45.
Function Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis.rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Protein Name D-Aminoacyl-Trna Deacylase 1
Dtd
Dna-Unwinding Element-Binding Protein B
Due-B
Gly-Trna(Ala Deacylase
Histidyl-Trna Synthase-Related
Database Links
Cellular Localisation Nucleus
Cytoplasm
Associated With Chromatin At Some Replication Origins Containing Functional Dna-Unwinding Elements
Alternative Protein Names D-Aminoacyl-Trna Deacylase 1 protein
Dtd protein
Dna-Unwinding Element-Binding Protein B protein
Due-B protein
Gly-Trna(Ala Deacylase protein
Histidyl-Trna Synthase-Related protein
DTD1 protein
C20orf88 protein
DUEB protein
HARS2 protein

Information sourced from Uniprot.org

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