Human F11 protein (Recombinant) (C-His) (STJP003629)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human F11-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | F11 |
| Gene ID | 2160 |
| Uniprot ID | FA11_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val625 |
Additional Info
| Post Translational Modifications | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated).the presence of negatively charged surfaces accelerates activation. Activated by F2 (thrombin).the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation. Autoactivated.the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis. |
| Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
| Protein Name | Coagulation Factor XiFxiPlasma Thromboplastin AntecedentPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9673221 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Coagulation Factor Xi proteinFxi proteinPlasma Thromboplastin Antecedent proteinPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain proteinF11 protein |
Information sourced from Uniprot.org