| Tissue Specificity | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. |
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. Phosphorylated at Thr-100 by STK16. Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7.this modification hinders trypsin-catalyzed proteolysis in vitro. Polyubiquitinated.this modification induces proteolytic degradation and is impaired by interaction with ZC3H15. |
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions. |
| Protein Name | Developmentally-Regulated Gtp-Binding Protein 1Drg-1Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3Nedd-3Translation Factor Gtpase Drg1Trafac Gtpase Drg1 |
| Database Links | Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusCytoplasmThe Drg1-Zc3h15/Dfrp1 Complex Associates With Polysomes |
| Alternative Protein Names | Developmentally-Regulated Gtp-Binding Protein 1 proteinDrg-1 proteinNeural Precursor Cell Expressed Developmentally Down-Regulated Protein 3 proteinNedd-3 proteinTranslation Factor Gtpase Drg1 proteinTrafac Gtpase Drg1 proteinDRG1 proteinNEDD3 protein |
Information sourced from Uniprot.org
