Human DOCK2 protein (Recombinant) (N-His) (STJP005777)

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STJP005777
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Short Description :Recombinant-Human DOCK2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:DOCK2
Gene ID:1794
Uniprot ID:DOCK2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ile390-Glu635
Function Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Protein Name Dedicator Of Cytokinesis Protein 2
Database Links Reactome: R-HSA-164944
Reactome: R-HSA-6798695
Reactome: R-HSA-8980692
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-983231
Cellular Localisation Endomembrane System
Peripheral Membrane Protein
Cytoplasm
Cytoskeleton
Colocalizes With F-Actin
Alternative Protein Names Dedicator Of Cytokinesis Protein 2 protein
DOCK2 protein
KIAA0209 protein

Information sourced from Uniprot.org