| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.03 ng/mL |
| Detection Limit: |
156-100 ng/ml |
| Short Description: |
This DNASE1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Conjugation: |
Biotin |
| Storage Instruction: |
Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: |
4 hours |
| Detection: |
Colorimetric |
| Gene Symbol: |
DNASE1 |
| Gene ID: |
1773 |
| Uniprot ID: |
DNAS1_HUMAN |
| Sample Type: |
serum, plasma and cell culture supernates |
| Tissue Specificity | Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva. |
| Post Translational Modifications | |
| Function | Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation. |
| Protein Name | Deoxyribonuclease-1Deoxyribonuclease IDnase IDornase Alfa |
| Database Links | |
| Cellular Localisation | SecretedZymogen GranuleNucleus EnvelopeSecretory ProteinStored In Zymogen Granules And Found In The Nuclear Envelope |
| Alternative ELISA Names | Deoxyribonuclease-1 ELISA kitDeoxyribonuclease I ELISA kitDnase I ELISA kitDornase Alfa ELISA kitDNASE1 ELISA kitDNL1 ELISA kitDRNI ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
