Human DMP1 protein (Recombinant) (C-His) (STJP013442)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DMP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM Histidine-HCl, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 6.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | DMP1 |
| Gene ID | 1758 |
| Uniprot ID | DMP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu17-Tyr513 |
Additional Info
| Post Translational Modifications | Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. |
| Function | May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. |
| Protein Name | Dentin Matrix Acidic Phosphoprotein 1Dmp-1Dentin Matrix Protein 1 |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | NucleusCytoplasmSecretedExtracellular SpaceExtracellular MatrixIn Proliferating Preosteoblasts It Is NuclearDuring Early Maturation Stage Is Cytoplasmic And In Mature Osteoblast Localizes In The Mineralized MatrixExport From The Nucleus Of Differentiating Osteoblast Is Triggered By The Release Of Calcium From Intracellular Stores Followed By A Massive Influx Of This Pool Of Calcium Into The Nucleus |
| Alternative Protein Names | Dentin Matrix Acidic Phosphoprotein 1 proteinDmp-1 proteinDentin Matrix Protein 1 proteinDMP1 protein |
Information sourced from Uniprot.org