Human DKK3 (DKK3) Sandwich ELISA Kit Kit (STJE0001898)

Human DKK3 (DKK3) Sandwich ELISA Kit Kit (STJE0001898)

SKU:
STJE0001898-96
£439.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 22.15 pg/mL
Detection Limit: 125-8000 pg/ml
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: DKK3
Gene ID: 27122
Uniprot ID: DKK3_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity Highest expression in heart, brain, and spinal cord.
Post Translational Modifications N- and O-glycosylated.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 3
Dickkopf-3
Dkk-3
Hdkk-3
Database Links
Cellular Localisation Secreted
Alternative ELISA Names Dickkopf-Related Protein 3 ELISA kit
Dickkopf-3 ELISA kit
Dkk-3 ELISA kit
Hdkk-3 ELISA kit
DKK3 ELISA kit
REIC ELISA kit
UNQ258 ELISA kit
PRO295 ELISA kit
output

Information sourced from Uniprot.org

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