Human DGKQ protein (Recombinant) (N-His) (STJP004907)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DGKQ-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DGKQ |
| Gene ID | 1609 |
| Uniprot ID | DGKQ_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro584-Ala721 |
Additional Info
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis. |
| Protein Name | Diacylglycerol Kinase ThetaDag Kinase ThetaDgkthetaDiglyceride Kinase ThetaDgk-Theta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | CytoplasmCytosolCell MembraneSynapseCytoskeletonNucleusNucleus SpeckleNucleus MatrixTranslocates To The Plasma Membrane In Response To Steroid Hormone Receptor StimulationTranslocation To The Plasma Membrane Is Dependent On G-Protein Coupled Receptor Stimulation And Subsequent Activation Of Prkce And Probably PrkchTranslocates To The Nucleus In Response To Thrombin Stimulation (Probable)Association With The Nuclear Matrix Is Regulated By Nerve Growth Factor |
| Alternative Protein Names | Diacylglycerol Kinase Theta proteinDag Kinase Theta proteinDgktheta proteinDiglyceride Kinase Theta proteinDgk-Theta proteinDGKQ proteinDAGK4 protein |
Information sourced from Uniprot.org