Human DCPS protein (Recombinant) (His-Tag) (STJP017292)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DCPS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCPS |
| Gene ID | 28960 |
| Uniprot ID | DCPS_HUMAN |
| Accession Number | NP_054745 |
| Immunogen | Human |
| Immunogen Region | 1-337aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in liver, brain, kidney, testis and prostate. |
| Function | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway.m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. |
| Protein Name | M7gpppx DiphosphataseDcs-1Decapping Scavenger EnzymeHint-Related 7megmp-Directed HydrolaseHistidine Triad Nucleotide-Binding Protein 5Histidine Triad Protein Member 5Hint-5Scavenger Mrna-Decapping Enzyme Dcps |
| Database Links | Reactome: R-HSA-429958 |
| Cellular Localisation | CytoplasmNucleusPredominantly Localized In The NucleusNucleocytoplasmic Shuttling Protein That Can Transiently Enter The Cytoplasm In Mammalian Cells In A Xpo1/Crm1-Dependent Manner |
| Alternative Protein Names | M7gpppx Diphosphatase proteinDcs-1 proteinDecapping Scavenger Enzyme proteinHint-Related 7megmp-Directed Hydrolase proteinHistidine Triad Nucleotide-Binding Protein 5 proteinHistidine Triad Protein Member 5 proteinHint-5 proteinScavenger Mrna-Decapping Enzyme Dcps proteinDCPS proteinDCS1 proteinHINT5 proteinHSPC015 protein |
Information sourced from Uniprot.org