| Function | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
| Protein Name | Drebrin-Like ProteinCervical Sh3p7Cervical Mucin-Associated ProteinDrebrin-FHpk1-Interacting Protein Of 55 KdaHip-55Sh3 Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6794361Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumRuffleCell CortexCytosolSynapsePerikaryonNeuron ProjectionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleClathrin-Coated Vesicle MembraneGolgi Apparatus MembranePodosomeEarly EndosomeDendritePostsynaptic DensityAssociates With Lamellipodial Actin And Membrane RufflesColocalizes With Actin And Cortactin At Podosome Dots And Podosome Rosettes |
| Alternative Protein Names | Drebrin-Like Protein proteinCervical Sh3p7 proteinCervical Mucin-Associated Protein proteinDrebrin-F proteinHpk1-Interacting Protein Of 55 Kda proteinHip-55 proteinSh3 Domain-Containing Protein 7 proteinDBNL proteinCMAP proteinSH3P7 proteinPP5423 protein |
Information sourced from Uniprot.org
