Human Crystallin mu/CRYM protein (Recombinant) (His-Tag) (STJP016699)

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STJP016699
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Crystallin mu/CRYM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRYM
Gene ID: 1428
Uniprot ID: CRYM_HUMAN
Immunogen Region: 1-314aa
Accession Number: NP_001879
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH> MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG
Tissue Specificity Expressed in neural tissues, muscle and kidney. Expressed in the inner ear.
Function Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates. Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK).
Protein Name Ketimine Reductase Mu-Crystallin
1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate Reductase
P2c/Pyr2c Reductase
Nadp-Regulated Thyroid-Hormone-Binding Protein
Database Links Reactome: R-HSA-71064
Cellular Localisation Cytoplasm
Alternative Protein Names Ketimine Reductase Mu-Crystallin protein
1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate Reductase protein
P2c/Pyr2c Reductase protein
Nadp-Regulated Thyroid-Hormone-Binding Protein protein
CRYM protein
THBP protein

Information sourced from Uniprot.org

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