| Function | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 1Ccr4-Associated Factor 1Negative Regulator Of Transcription Subunit 1 HomologNot1hHnot1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmP-BodyNucleusNanos2 Promotes Its Localization To P-Body |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 1 proteinCcr4-Associated Factor 1 proteinNegative Regulator Of Transcription Subunit 1 Homolog proteinNot1h proteinHnot1 proteinCNOT1 proteinCDC39 proteinKIAA1007 proteinNOT1 proteinAD-005 protein |
Information sourced from Uniprot.org
