Human CNGA1 protein (Recombinant) (N-His) (STJP010894)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CNGA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CNGA1 |
| Gene ID | 1259 |
| Uniprot ID | CNGA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu446-Thr686 |
Additional Info
| Function | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-1Cng Channel Alpha-1Cng-1Cng1Cyclic Nucleotide-Gated Channel - PhotoreceptorRod Photoreceptor Cgmp-Gated Cation Channel Subunit AlphaCgmp-Gated Cation Channel Alpha-1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Cyclic Nucleotide-Gated Channel Alpha-1 proteinCng Channel Alpha-1 proteinCng-1 proteinCng1 proteinCyclic Nucleotide-Gated Channel - Photoreceptor proteinRod Photoreceptor Cgmp-Gated Cation Channel Subunit Alpha proteinCgmp-Gated Cation Channel Alpha-1 proteinCNGA1 proteinCNCG proteinCNCG1 protein |
Information sourced from Uniprot.org