Human CIRBP protein (Recombinant) (His-Tag) (STJP017169)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CIRBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% Glycerol, 0.2M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIRBP |
| Gene ID | 1153 |
| Uniprot ID | CIRBP_HUMAN |
| Accession Number | NP_001271 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. |
| Protein Name | Cold-Inducible Rna-Binding ProteinA18 HnrnpGlycine-Rich Rna-Binding Protein Cirp |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmCytoplasmTranslocates From The Nucleus To The Cytoplasm After Exposure To Uv RadiationTranslocates From The Nucleus To The Cytoplasm Into Stress Granules Upon Various Cytoplasmic StressesSuch As Osmotic And Heat ShocksIts Recruitment Into Stress Granules Occurs In The Absence Of Tiar Proteins |
| Alternative Protein Names | Cold-Inducible Rna-Binding Protein proteinA18 Hnrnp proteinGlycine-Rich Rna-Binding Protein Cirp proteinCIRBP proteinA18HNRNP proteinCIRP protein |
Information sourced from Uniprot.org