Human CIDEA protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007712)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CIDEA-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CIDEA |
| Gene ID | 1149 |
| Uniprot ID | CIDEA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg35-Lys104 |
Additional Info
| Function | Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis.the physiological significance of its role in apoptosis is unclear. |
| Protein Name | Lipid Transferase CideaCell Death Activator Cide-ACell Death-Inducing Dffa-Like Effector A |
| Database Links | Reactome: R-HSA-8964572Reactome: R-HSA-9844594 |
| Cellular Localisation | Lipid DropletNucleusEnriched At Lipid Droplet Contact Sites |
| Alternative Protein Names | Lipid Transferase Cidea proteinCell Death Activator Cide-A proteinCell Death-Inducing Dffa-Like Effector A proteinCIDEA protein |
Information sourced from Uniprot.org