Human CHI3L1 protein (Recombinant) (C-His) (STJP013318)

Name: Human CHI3L1 protein (Recombinant) (C-His) (STJP013318)
SKU: STJP013318-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013318-100

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Short Description	Recombinant-Human CHI3L1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 300mM NaCl, 2mM EDTA, pH 8.5.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	Glycosylated.
Function	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name	Chitinase-3-Like Protein 1 39 Kda Synovial Protein Cartilage Glycoprotein 39 Cgp-39 Gp-39 Hcgp-39 Ykl-40
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted Extracellular Space Cytoplasm Perinuclear Region Endoplasmic Reticulum
Alternative Protein Names	Chitinase-3-Like Protein 1 protein 39 Kda Synovial Protein protein Cartilage Glycoprotein 39 protein Cgp-39 protein Gp-39 protein Hcgp-39 protein Ykl-40 protein CHI3L1 protein

Information sourced from Uniprot.org