Human CHD1 protein (Recombinant) (N-His) (STJP008304)

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STJP008304
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CHD1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CHD1
Gene ID: 1105
Uniprot ID: CHD1_HUMAN
Immunogen Region: Ser1127-Thr1285
Immunogen: Homo sapiens (Human)
Function ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Protein Name Chromodomain-Helicase-Dna-Binding Protein 1
Chd-1
Atp-Dependent Helicase Chd1
Database Links Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Cytoplasm
Is Released Into The Cytoplasm When Cells Enter Mitosis And Is Reincorporated Into Chromatin During Telophase-Cytokinesis
Alternative Protein Names Chromodomain-Helicase-Dna-Binding Protein 1 protein
Chd-1 protein
Atp-Dependent Helicase Chd1 protein
CHD1 protein

Information sourced from Uniprot.org

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