Human CES1 protein (Recombinant) (N-His) (STJP006596)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CES1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CES1 |
| Gene ID | 1066 |
| Uniprot ID | EST1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly18-Leu299 |
Additional Info
| Post Translational Modifications | Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile. |
| Protein Name | Liver Carboxylesterase 1Acyl-Coenzyme A -Cholesterol AcyltransferaseAcatBrain Carboxylesterase Hbr1Carboxylesterase 1Ce-1Hce-1Cholesteryl Ester HydrolaseCehCocaine CarboxylesteraseEgasynHmseMethylumbelliferyl-Acetate Deacetylase 1Monocyte/Macrophage Serine EsteraseRetinyl Ester HydrolaseRehSerine Esterase 1Triacylglycerol HydrolaseTgh |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-211945Reactome: R-HSA-5578768Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmLipid DropletMoves From Cytoplasm To Lipid Droplets Upon Lipid LoadingAssociates With Lipid Droplets Independently Of Triglycerides (Tg) Content Of The Droplets And Hydrolyzes Cholesteryl Esters More Efficiently From Mixed Droplets |
| Alternative Protein Names | Liver Carboxylesterase 1 proteinAcyl-Coenzyme A -Cholesterol Acyltransferase proteinAcat proteinBrain Carboxylesterase Hbr1 proteinCarboxylesterase 1 proteinCe-1 proteinHce-1 proteinCholesteryl Ester Hydrolase proteinCeh proteinCocaine Carboxylesterase proteinEgasyn proteinHmse proteinMethylumbelliferyl-Acetate Deacetylase 1 proteinMonocyte/Macrophage Serine Esterase proteinRetinyl Ester Hydrolase proteinReh proteinSerine Esterase 1 proteinTriacylglycerol Hydrolase proteinTgh proteinCES1 proteinCES2 proteinSES1 protein |
Information sourced from Uniprot.org