Human CDK11B protein (Recombinant) (N-His) (STJP015299)

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STJP015299
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CDK11B-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: CDK11B
Gene ID: 984
Uniprot ID: CD11B_HUMAN
Immunogen Region: Ser434-Thr726
Immunogen: Homo sapiens (Human)
Post Translational Modifications During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
Function Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Protein Name Cyclin-Dependent Kinase 11b
Cell Division Cycle 2-Like Protein Kinase 1
Clk-1
Cell Division Protein Kinase 11b
Galactosyltransferase-Associated Protein Kinase P58/Gta
Pitslre Serine/Threonine-Protein Kinase Cdc2l1
P58 Clk-1
Database Links Reactome: R-HSA-380270
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Cyclin-Dependent Kinase 11b protein
Cell Division Cycle 2-Like Protein Kinase 1 protein
Clk-1 protein
Cell Division Protein Kinase 11b protein
Galactosyltransferase-Associated Protein Kinase P58/Gta protein
Pitslre Serine/Threonine-Protein Kinase Cdc2l1 protein
P58 Clk-1 protein
CDK11B protein
CDC2L1 protein
CDK11 protein
PITSLREA protein
PK58 protein

Information sourced from Uniprot.org