Human CDC5L protein (Recombinant) (N-His) (STJP011348)

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STJP011348
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Short Description :Recombinant-Human CDC5L-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:CDC5L
Gene ID:988
Uniprot ID:CDC5L_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser591-Glu851
Post Translational Modifications Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Function DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Protein Name Cell Division Cycle 5-Like Protein
Cdc5-Like Protein
Pombe Cdc5-Related Protein
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
May Shuttle Between Cytoplasm And Nucleus
Alternative Protein Names Cell Division Cycle 5-Like Protein protein
Cdc5-Like Protein protein
Pombe Cdc5-Related Protein protein
CDC5L protein
KIAA0432 protein
PCDC5RP protein

Information sourced from Uniprot.org

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